Osteoporosis is a common metabolic bone disease, which is more common in postmenopausal women. The incidence of osteoporosis in men is only one sixth of that in women. Under the action of general external forces, osteoporotic patients can have fractures.
Osteoporosis in postmenopausal women is related to endogenous estrogen. The decrease of estrogen, the decrease of inhibition on osteoclasts, the relative strengthening of osteoclasts, the imbalance between osteoclasts and osteoblasts, the increase of bone absorption and the decrease of bone formation lead to the gradual loss of bone.
Because of the decline of ovarian function, endocrine changes and the gradual atrophy of reproductive organs in menopausal women, this change will also affect the osteogenic process of osteoblasts. Before and after menopause, the level of estrogen secretion decreased, bone absorption exceeded bone formation, and the balance mechanism was hindered.
Therefore, bone loss gradually increases in this stage, leading to osteoporosis. In this case, the incidence of fracture also increases, and the earlier the menopause age, the earlier it occurs.